Mobility in the Field of Nanoparticles and Radiosensitizers (NanoMove)

The NanoMove project focuses on developing internationalisation and enhancing the quality of the research environment at the J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences. The project comprehensively supports two MSCA projects that received high evaluation scores but could not be funded due to a lack of financial resources in the given call: 1) DNA-based composites, 2) Quantification of the efficiency of radiosensitizers and nanoparticles using electron-induced chemistry in a liquid microjet. Ad 1) The DOBCOS project aims to develop novel composites trough the controlled assembly of different microparticles, using DNA origami as a construction method, combined with functional molecules and precise chemical modifications to fabricate stable, controllable composites structures. This innovative approach will drive advancements in nanophotonics and optical manipulation studies. Ad 2) This project aims to enhance in-situ radiation dosimetry, explore DNA damage mechanisms, and evaluate therapeutic enhancers in aqueous environments. It focuses on developing chemical dosimetry techniques, monitoring reactive species in real time, studying low-energy electron damage to plasmid DNA, and assessing radiosensitizers and nanoparticles for improved radiation therapy. The research will provide insights into radiation interactions, enabling more accurate dosimetry and better treatments.