Postdoctoral Position in the Molecular Modeling of Processes in Enzyme Assemblies

The Timr group at the J. Heyrovský Institute of Physical Chemistry in Prague is seeking a highly motivated postdoctoral associate to work on multi-scale modeling of dynamic enzyme assemblies.

Our research group focuses on the computer simulation of the cell interior. Using multi-scale computational models, we aim to elucidate the physical and chemical mechanisms governing the organization of metabolic pathways in living cells. Supported by the Lumina Quaeruntur Award and a grant from the Czech Science Foundation, our team is integrated into the interdisciplinary Department of Computational Chemistry. This department bridges the physical chemistry and biophysics of proteins and membranes with theoretical enzymology and spectroscopy.

The postdoctoral associate will contribute to the implementation and deployment of a multi-scale framework to couple molecular simulations of enzymes and ligands in dynamic enzyme assemblies with kinetic models of metabolic pathways. This framework will allow us to explore mechanisms underlying spatial organization and control of metabolic pathways in cells.

The initial contract period is for one year with the possibility of extending up to three years.

Requirements:

• PhD in Physics, Physical Chemistry, Computational Biology, or a related field 
• Proficiency in scientific programming (e.g., Python, C, C++) 
• Strong skills in developing and implementing mathematical models of molecular processes 
• Experience with coarse-grained and all-atom classical MD simulations 
• Excellent communication and collaboration skills 

Experience with protein modeling, computational software development, and developing software interfaces to integrate different simulation programs will be considered an asset. 

Benefits: 

• Pension contribution 
• Language courses at a reduced price
• 25 days of vacation + 5 days of personal leave and 3 sick days   
• Flexible working-time, the possibility of part-time work, work-life balance 
• Pension contribution 
• Possibility of attending children groups of the CAS
• Possibility to use discounts in recreation centers of the CAS
• Sports goods rental, free parking, trade union library
• Attractive location
• Possibility of further career and personal development (trainings, workshops)

To apply, please send your CV, a list of publications, a motivation letter, and contact information for two references to recruitmentjh-inst.cas.cz (recruitment[at]jh-inst[dot]cas[dot]cz) and stepan.timrjh-inst.cas.cz (stepan[dot]timr[at]jh-inst[dot]cas[dot]cz). Please include SC2024_36 in the email subject line. 

Starting date: January 2025

Type of contract: Temporary

Job status: Full time 

Selection process

By providing us with your personal data in your CV, you have allowed J. Heyrovský Institute of Physical Chemistry to process and file your CV in the HR database. Your personal data will be used for the internal HR needs of the J. Heyrovský Institute of Physical Chemistry only. At the same time, you confirm herewith that the personal data as stated in the CV you have sent to us is true and accurate.